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Metformin alleviates stroke severity in female mice with chronic kidney disease through AMPK activation and subsequent decrease of microglia/macrophages M1 polarization

Archive ouverte | Grissi, Maria | CCSD

56th Congress of the European-Renal-Association (ERA)-European-Dialysis-and-Transplant-Association (EDTA) - Burden, Access and Disparities in Kidney Disease, Budapest, HUNGARY, JUN 13-16, 2019. International audience

Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease

Archive ouverte | Henaut, Lucie | CCSD

International audience. Ischemic stroke is highly prevalent in chronic kidney disease (CKD) patients and has been associated with a higher risk of neurological deterioration and in-hospital mortality. To date, littl...

Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Archive ouverte | Grissi, Maria | CCSD

International audience. Chronic kidney disease (CKD) worsens ischemic stroke severity in both patients and animals. In mice, these poorer functional outcomes are associated with decreased brain activity of AMP-activ...

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