Targeting a Gpcr, Prokineticin Receptor-1, Protects Heart Against Doxorubicin-Mediated Cardiotoxicity

Archive ouverte | Nebigil, Canan G | CCSD

Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection

Archive ouverte | Gasser, Adeline | CCSD

International audience. OBJECTIVES This study investigated how different concentrations of doxorubicin (DOX) can affect the function of cardiac cells. This study also examined whether activation of prokineticin rece...

DEVELOPMENTALLY REGULATED SEROTONIN 5-HT 2B RECEPTORS

Archive ouverte | Nebigil, C.G. | CCSD

International audience. Serotonin (5-hydroxytryptamine, 5-HT) binds to numerous cognate receptors to initiate its biological effects. In this review, we have focused on the 5-HT2B receptor to address how signaling a...