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Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

Archive ouverte | Wigger, Leonore | CCSD

International audience. Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma ...

Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice

Archive ouverte | Laperrousaz, Elise | CCSD

International audience. Aims/hypothesis Regulation of energy balance involves the participation of many factors, including nutrients, among which are circulating lipids, acting as peripheral signals informing the ce...

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

Archive ouverte | Campana, Mélanie | CCSD

International audience. Objectives: Hypothalamic lipotoxicity has been shown to induce central insulin resistance and dysregulation of glucose homeostasis; nevertheless, elucidation of the regulatory mechanisms rema...

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