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Study of structural and functional dynamics of translocator protein, a new target for treatment of malaria. Étude de la dynamique structurale et fonctionnelle de la protéine translocatrice, une nouvelle cible pour traiter le paludisme

Archive ouverte | Mallenahalli Rao, Rajas | CCSD

Despite availability of different drugs, malaria remains a serious health challenge in tropical countries, and is rapidly making inroads in the countries with temperate climate. To compound the problem, resistance to the antimalar...

Effects of changes in glycan composition on glycoprotein dynamics: example of N -glycans on insulin receptor

Archive ouverte | Rao, Rajas, M | CCSD

International audience. Abstract Glycosylation is among the most common post-translational modifications in proteins, although it is observed in only about 10% of all the protein structures in protein data bank (PDB...

Differential MMP-14 Targeting by Biglycan, Decorin, Fibromodulin and Lumican Unraveled by In Silico Approach

Archive ouverte | Rivet, Romain | CCSD

International audience. Small leucine-rich proteoglycans (SLRPs) are major regulators of extracellular matrix assembly and cell signaling. Lumican, a member of the SLRPs family, and its derived peptides were shown t...

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