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Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail

Archive ouverte | Masino, Laura | CCSD

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Pathogenic and non-pathogenic polyglutamine tracts have similar structural properties: towards a length-dependent toxicity gradient.

Archive ouverte | Klein, Fabrice a C | CCSD

Abnormally expanded polyglutamine (polyQ) tracts provide a gain of toxic functions to nine otherwise unrelated human proteins and induce progressive neurodegenerative diseases. Over the past ten years, it was suggested that only p...

Conformational Plasticity of proNGF

Archive ouverte | Paoletti, Francesca | CCSD

International audience. Nerve Growth Factor is an essential protein that supports neuronal survival during development and influences neuronal function throughout adulthood, both in the central and peripheral nervou...

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