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Voriconazole topical cream formulation: evidence for stability and antifungal activity

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Bouchand, Camille | Nguyen, David | Secretan, Philippe-Henri | Vidal, Fabrice | Guery, Romain | Auvity, Sylvain | Cohen, Jeremie F. | Lanternier, Fanny | Lortholary, Olivier | Cisternino, Salvatore | Schlatter, Joël

Edité par CCSD -

International audience. Systemic use of voriconazole (VCZ) might be restricted by adverse events, such as hepatotoxicity and neurotoxicity, or drug-drug interactions. Topical VCZ application to skin may help to treat local infection more effectively and limit unwanted whole-body exposure. Topical VCZ cream was stable for 90 days when refrigerated. A patient with cutaneous Fusarium solani infection on his right forearm was successfully treated with topical 1% VCZ cream after failure of oral VCZ treatment.

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