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Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Archive ouverte | Just, Pierre-Alexandre | CCSD

International audience. Abstract Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of liver kinase B1 (Lkb1) ...

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer

Archive ouverte | Wassef, Michel | CCSD

International audience. Genetic mutations affecting chromatin modifiers are widespread in cancers. In malignant peripheral nerve sheath tumors (MPNSTs), Polycomb repressive complex 2 (PRC2), which plays a crucial ro...

Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma?

Archive ouverte | Kime, Amel | CCSD

International audience. Context.— A correlation between the morphology of ovarian high-grade serous carcinomas (HGSOCs) and BRCA mutations has been previously reported. Objective.— To investigate, beyond BRCA, the a...

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