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SGLT2 expression in human vasculature and heart correlates with low-grade inflammation and causes eNOS-NO/ROS imbalance

Archive ouverte | Mroueh, Ali | CCSD

International audience. Abstract Aims Sodium-glucose co-transporter 2 inhibitors (SGLT2i) show a cardioprotective effect in heart failure and myocardial infarction, pathologies often associated with low-grade inflam...

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Archive ouverte | Hmadeh, Sandy | CCSD

International audience. HIGHLIGHTSSubclinical leaflet thrombosis was recently linked to higher rates of stroke and transient ischemic attack after TAVR. EVs have emerged as a surrogate marker of endothelial dysfunct...

Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression

Archive ouverte | Jesel, Laurence | CCSD

International audience. Background: Whilst the link between aging and thrombogenicity in atrial fibrillation (AF) is well established, the cellular underlying mechanisms are unknown. In AF, the role of senescence in...

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