Subclinical leaflet thrombosis was recently linked to higher rates of stroke and transient ischemic attack after TAVR. EVs have emerged as a surrogate marker of endothelial dysfunction and cardiovascular risk. This study demonstrates the role of EVs trapped within the native aortic valve in valvular dysfunction and thrombogenicity, and points at the contribution of the local angiotensin system/NADPH oxidases/SGLT2 pro-oxidant pathway.