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Immunotherapy and patients treated for cancer with microsatellite instability. Immunothérapie et patients traités pour cancer avec instabilité des microsatellites

Archive ouverte | Colle, Raphaël | CCSD

International audience. Microsatellite instability (MSI) is a tumor phenotype linked to somatic or germline (Lynch syndrome) inactivating alterations of DNA mismatch repair genes. A broad spectrum of neoplasms exhib...

Pseudoprogression in patients treated with immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer

Archive ouverte | Colle, Raphael | CCSD

International audience

Lynch syndrome: What is new?. Syndrome de Lynch : quoi de neuf ?

Archive ouverte | Pellat, Anna | CCSD

International audience. Lynch syndrome is a genetic condition defined by a germline mutation of an MMR (MisMatch Repair) gene leading to a defective DNA MMR system. Therefore, it is characterized by the predispositi...

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