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ATP citrate lyase: A central metabolic enzyme in cancer

Archive ouverte | Icard, Philippe | CCSD

International audience. ACLY links energy metabolism provided by catabolic pathways to biosynthesis. ACLY, which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA and OAA. The firs...

The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response

Archive ouverte | Icard, Philippe | CCSD

International audience. Current mortality due to the Covid-19 pandemic (approximately 1.2 million by November 2020) demonstrates the lack of an effective treatment. As replication of many viruses - including MERS-Co...

Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update

Archive ouverte | Icard, Philippe | CCSD

International audience. Citrate plays a central role in cancer cells’ metabolism and regulation. Derived from mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate lyase into ...

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