Syracuse

In vivo effectiveness of carbonated calcium‐deficient hydroxyapatite‐coated activated carbon fiber cloth on bone regeneration

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Olivier, Florian | Sarou‐kanian, Vincent | Fayon, Franck | Bonnamy, Sylvie | Rochet, Nathalie

Edité par CCSD ; Wiley -

International audience. We have previously shown that activated carbon fiber cloth (ACC) either uncoated or coated with carbonated calcium-deficient hydroxyapatite (CDA), namely ACC and ACC/CDA, were biocompatible in vitro with human osteoblasts. Here we hypothesized that ACC and ACC/CDA could be used as tissue patches in vivo to accelerate wounded bone healing. In a model of rat femoral defect, we have compared spontaneous cortical bone regeneration with regeneration in the presence of ACC and ACC/CDA patches. At day 7, 14 and 21, bone formation was evaluated using micro computed tomography (µCT), magnetic resonance imaging (MRI) and histological analysis. Our results demonstrate first that these ACC tissues are highly biocompatible in vivo, and second that ACC/CDA patches apposition results in the acceleration of bone reconstruction due to a guiding action of the ACC fibers and an osteogenic effect of the CDA phase. We guess that this approach may represent a valuable strategy to accelerate bone regeneration in human.

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