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Organs on chip approach: a tool to evaluate cancer -immune cells interactions

Archive ouverte | Biselli, Elena | CCSD

In this paper we discuss the applicability of numerical descriptors and statistical physics concepts to characterize complex biological systems observed at microscopic level through organ on chip approach. To this end, we employ d...

CausalXtract: a flexible pipeline to extract causal effects from live-cell time-lapse imaging data

Archive ouverte | Simon, Franck | CCSD

International audience. Live-cell microscopy routinely provides massive amount of time-lapse images of complex cellular systems under various physiological or therapeutic conditions. However, this wealth of data rem...

Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip

Archive ouverte | Veith, Irina | CCSD

International audience. There is a compelling need for approaches to predict the efficacy of immunotherapy drugs. Tumor-on-chip technology exploits microfluidics to generate 3D cell co-cultures embedded in hydrogels...

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