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Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Archive ouverte | Rubio, Karla | CCSD

International audience. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly ...

Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

Archive ouverte | Dobersch, Stephanie | CCSD

International audience. Abstract In addition to nucleosomes, chromatin contains non-histone chromatin-associated proteins, of which the high-mobility group proteins are the most abundant. Chromatin-mediated regulati...

Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer

Archive ouverte | Rubio, Karla | CCSD

International audience. Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an important role...

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