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Archive ouverte | Gregoire, Elodie, P | CCSD

International audience. Testis differentiation requires high levels of proliferation of progenitor cells that give rise to two cell lineages forming the testis, the Sertoli and the Leydig cells. Hence defective cell...

R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiation.

Archive ouverte | Chassot, Anne-Amandine | CCSD

International audience. Sex differentiation is a unique developmental process. Starting from a bipotential gonad, it gives rise to the ovary and the testis, two highly specialized organs that differ morphologically ...

Involvement of FOXL2 and RSPO1 in ovarian determination, development, and maintenance in mammals

Archive ouverte | Pannetier, Maëlle | CCSD

International audience. In mammals, sex determination is a process through which the gonad is committed to differentiate into a testis or an ovary. This process relies on a delicate balance between genetic pathways ...

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