X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom

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Sotiropoulos, Marios | Brisebard, Elise | Le Dudal, Marine | Jouvion, Gregory | Juchaux, Marjorie | Crépin, Delphine | Sebrie, Catherine | Jourdain, Laurene | Labiod, Dalila | Lamirault, Charlotte | Pouzoulet, Frederic | Prezado, Yolanda

Edité par CCSD ; Elsevier -

International audience. Minibeam radiation therapy (MBRT) is a type of spatial fractionated radiotherapy that uses submillimetric beams. This work reports on a pilot study on normal tissue response and the increase of the lifespan of glioma-bearing rats when irradiated with a tabletop x-ray system. Our results show a significant widening of the therapeutic window for brain tumours treated with MBRT: an important proportion of long-term survivals (60%) coupled with a significant reduction of toxicity when compared with conventional (broad beam) irradiations. In addition, the clinical translation of the minibeam treatment at a conventional irradiator is evaluated through a possible human head treatment plan

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