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Rapid synaptogenesis in the Nucleus Accumbens is induced by a single cocaine administration and stabilized by MAP Kinase interacting kinase 1 activity

Archive ouverte | dos Santos, Marc | CCSD

International audience. Background: Repeated cocaine exposure produces new spine formation in Striatal Projection Neurons (SPNs) of the Nucleus Accumbens (NAc). However, an acute exposure to cocaine can trigger long...

Rapid Synaptogenesis in the Nucleus Accumbens Is Induced by a Single Cocaine Administration and Stabilized by Mitogen-Activated Protein Kinase Interacting Kinase-1 Activity

Archive ouverte | dos Santos, Marc | CCSD

International audience. Background: Repeated cocaine exposure produces new spine formation in striatal projection neurons (SPNs) of the nucleus accumbens. However, an acute exposure to cocaine can trigger long-lasti...

A new automated 3D detection of synaptic contacts reveals the formation of cortico-striatal synapses upon cocaine treatment in vivo

Archive ouverte | Heck, Nicolas | CCSD

International audience. Addiction can be considered as a form of neuronal adaptation within the reward circuitry. Upon psychostimulant administration, long-term behavioral adaptations are associated with synaptic pl...

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