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Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function

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Denarier, E. | Ecklund, K. | Berthier, G. | Favier, A. | O'Toole, E | Gory-Fauré, S. | de Macedo, L. | Delphin, C. | Andrieux, A. | Markus, S. | Boscheron, C.

Edité par CCSD ; American Society for Cell Biology -

International audience. The authors of this study employ budding yeast to model a disease-correlated tubulin mutation to determine how it leads to microtubule dysfunction. They find that the mutation leads to alterations in microtubule dynamics, tubulin isotype usage, and a spindle positioning defect that is due to disrupted microtubule-binding by a dynein regulator.

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