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Presence of SARS-CoV-2 in a Cornea Transplant

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Otmani Idrissi, Myriem | Baudoin, Jean-Pierre | Chateau, Anne-Line | Aherfi, Sarah | Bedotto-Buffet, Marielle | Latil, Alain | Lepidi, Hubert | Chiaroni, Jacques | Picard, Christophe | Mege, Jean-Louis | La Scola, Bernard | Mezouar, Soraya

Edité par CCSD ; MDPI -

International audience. Background: The SARS-CoV-2 pandemic has impacted tissue transplantation procedures since conjunctivas were found to be associated with coronavirus infection. Here, we investigated infection of a cornea graft from a COVID-19-positive donor.Methods: In order to evaluate the presence of SARS-CoV-2 in the cornea graft we first carried out a qRT-PCR and then we investigated the presence of SARS-CoV-2 by fluorescence and electron microscopy.Conclusions: Although the cornea graft was found to be negative by qRT-PCR, we were able to show the presence of SARS-CoV-2 in corneal cells expressing the SARS-CoV-2 receptor, ACE2. Taken together, our findings may have important implications for the use of corneal tissue in graft indications and open the debate on SARS-CoV-2 transmissibility.

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