Regulatory T Cells Increase After rh-MOG Stimulation in Non-Relapsing but Decrease in Relapsing MOG Antibody-Associated Disease at Onset in Children

Archive ouverte

Horellou, Philippe | de Chalus, Aliénor | Giorgi, Laetitia | Leroy, Carole | Chrétien, Pascale | Hacein-Bey-Abina, Salima | Bourgeois, Christine | Mariette, Xavier | Serguera, Ché | Le Grand, Roger | Deiva, Kumaran

Edité par CCSD ; Frontiers -

International audience. MOGAD. Increase of Th17 cells was significant in MOGNR (means: 0.63 ± 0.15 vs. 1.36 ± 0.43; Wilcoxon-test p = 0.03) but not in MOGR. CD4 + T regs were significantly increased in MOGNR (means: 3.51 ± 0.7 vs. 4.59 ± 1.33; Wilcoxon-test p = 0.046) while they decreased in MOGR. CD45RA-Foxp3 + T regs were significantly decreased in MOGR (means: 2.37 ± 0.23 vs. 1.99 ± 0.17; paired t-test p = 0.021), but not in MOGNR. MOGR showed the highest ratio of effector T regs /non suppressive-T regs, which was significantly higher than in MOGNR. Conclusions: Our findings suggest that CD4 + Th2 and Th17 cells are involved in the pathophysiology of MOGAD in children. The opposite response of T regs to rh-MOG in MOGNR, where CD4 + T regs increased, and in MOGR, where CD45RA-Foxp3 + T regs decreased, suggests a probable loss of tolerance toward MOG autoantigen in MOGR which may explain relapses in this recurrent pediatric autoimmune disease.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion