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Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes

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Beaujois, Rémy | Riquet, Franck | Cailliau-Maggio, Katia | Browaeys-Poly, Edith | Russo, Christophe | Blossey, Ralf | Vicogne, Dorothee | Marin, Matthieu | Lescuyer, Arlette | Vilain, Jean-Pierre | Bodart, Jean-Francois

Edité par CCSD ; PAGEPress -

The mitogen-activated protein kinase (MAPK) cascade in Xenopus oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found to be strongly ultrasensitive. We argue that underlying this behaviour is a regulation motif akin to a feed-forward loop acting in vivo.

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