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Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan.

Archive ouverte | Doz, Emilie | CCSD

Mycobacterium tuberculosis lipomannans (LMs) modulate the host innate immune response. The total fraction of Mycobacterium bovis BCG LM was shown both to induce macrophage activation and pro-inflammatory cytokines through Toll-lik...

Mycobacterial phosphatidyl inositol mannosides negatively regulate host toll-like receptor 4, MYD88-dependent proinflammatory cytokines and trif-dependent co-stimulatory molecules expression.

Archive ouverte | Doz, Emilie | CCSD

International audience. Mycobacterium tuberculosis modulates host immune responses through proteins and complex glycolipids. Here, we report that the GPI anchor phosphatidyl-myo-inositol hexa-mannosides (PIM6) or PI...

IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection.

Archive ouverte | Fremond, Cecile M | CCSD

MyD88, the common adapter involved in TLR, IL-1, and IL-18 receptor signaling, is essential for the control of acute Mycobacterium tuberculosis (MTB) infection. Although TLR2, TLR4, and TLR9 have been implicated in the response to...

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