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DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression

Archive ouverte | Perrard, Jérôme | CCSD

International audience. HPV16 is the most carcinogenic human papilloma-virus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis re...

The exon junction complex core factor eIF4A3 is a key regulator of HPV16 gene expression

Archive ouverte | Meznad, Koceila | CCSD

International audience. High-risk human papillomavirus (hrHPVs), particularly HPV16 and HPV18, are the etiologic factors of ano-genital cancers and some head and neck squamous cell carcinomas (HNSCCs). Viral E6 and ...

5azadC treatment upregulates miR-375 level and represses HPV16 E6 expression

Archive ouverte | Morel, Adrien | CCSD

International audience. High-risk human papillomaviruses are the etiological agents of cervical cancer and HPV16 is the most oncogenic genotype. Immortalization and transformation of infected cells requires the over...

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