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Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury

Archive ouverte | Panel, Mathieu | CCSD

International audience. Background & Aims: Hepatic ischemia-reperfusion injury is a complication of liver surgery that involves mitochondrial dysfunction resulting from mitochondrial permeability transition pore (mP...

The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia–reperfusion injury via mitoprotection

Archive ouverte | Kheyar, Amel | CCSD

International audience. Study of the ability to inhibit CypD peptidyl-prolyl cis-trans isomerase (PPIase) activity and of mitoprotective propertiesCypD PPIase activity assay Mitochondrial swelling assay Mitochondria...

Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti- Flaviviridae Activity

Archive ouverte | Nevers, Quentin | CCSD

International audience. Although members of the Flaviviridae display high incidence, morbidity, and mortality rates, the development of specific antiviral drugs for each virus is unlikely. Cyclophilins, a family of ...

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