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The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia–reperfusion injury via mitoprotection

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Kheyar, Amel | Ahnou, Nazim | Ahmed-Belkacem, Abdelhakim | Hulin, Anne | Pressiat, Claire | Ghaleh, Bijan | Guichou, Jean-François | Morin, Didier | Pawlotsky, Jean-Michel | Teixeira-Clerc, Fatima

Edité par CCSD ; Elsevier -

International audience.

Study of the ability to inhibit CypD peptidyl-prolyl cis-trans isomerase (PPIase) activity and of mitoprotective properties

CypD PPIase activity assay

Mitochondrial swelling assay
Mitochondrial calcium retention capacity assay
Isolated mouse liver mitochondria 1 compound
Study of the ability to inhibit mitochondrial permeability transition pore opening and cell death
In vitro hypoxia/reoxygenation model
Mouse hepatocyte cell line
Study of the hepatoprotective properties
Identification of credible lead compound for subsequent clinical development

In vivo hepatic ischemia/reperfusion injury model

compounds
Cyclophilin inhibitor synthesis

Chemical optimization R1

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