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Cardiac Gene Therapy with PDE2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure

Archive ouverte | Kamel, Rima | CCSD

International audience. BACKGROUND: Phosphodiesterase 2 (PDE2) is upregulated in human heart failure (HF). Cardiac PDE2-transgenic mice are protected against contractile dysfunction and arrhythmias in HF but whether...

Cardiac gene therapy with PDE2A limits remodeling and arrhythmias in mouse models of heart failure induced by catecholamines

Archive ouverte | Kamel, Rima | CCSD

International audience. ABSTRACT BACKGROUND Constitutive cardiac PDE2 activation was shown to protect against contractile dysfunction and arrhythmia in heart failure (HF). However, it remains unknown whether an acut...

Cardiac overexpression of PDE4B blunts β-adrenergic response and maladaptive remodeling in heart failure

Archive ouverte | Karam, Sarah | CCSD

International audience. Background The cAMP-hydrolyzing phosphodiesterase 4B (PDE4B) is a key negative regulator of cardiac β-adrenergic (β-AR) stimulation. PDE4B deficiency leads to abnormal Ca2+ handling and PDE4B...

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