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The catalytic properties of DNA G-quadruplexes rely on their structural integrity

Archive ouverte | Chen, Jielin | CCSD

International audience. The influence of the G-quartet structural integrity on the catalytic activity of the G-quadruplex (G4) was investigated by comparing the G4-DNAzyme performances of a series of G4s with a G-va...

A Push-Pull Mechanism Helps Design Highly Competent G-Quadruplex-DNA Catalysts

Archive ouverte | Chen, Jielin | CCSD

International audience. Massive efforts are currently being invested to improve the performance, versatility, and scope of applications of nucleic acid catalysts. G-quadruplex (G4)/hemin DNAzymes are of particular i...

The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology

Archive ouverte | Chen, Jielin | CCSD

International audience. Abstract Genomic sequences susceptible to form G-quadruplexes (G4s) are always flanked by other nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA oli...

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