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Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma

Archive ouverte | L’hermitte, Antoine | CCSD

International audience. Leukocyte cell-derived chemotaxin-2 (LECT2) was originally identified as a hepatocyte-secreted chemokine-like factor and a positive target of β-catenin signaling. Here, we dissected out the m...

Polyploidy spectrum: a new marker in HCC classification

Archive ouverte | Bou-Nader, Myriam | CCSD

International audience. OBJECTIVES: Polyploidy is a fascinating characteristic of liver parenchyma. Hepatocyte polyploidy depends on the DNA content of each nucleus (nuclear ploidy) and the number of nuclei per cell...

Deleting the β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth

Archive ouverte | Loesch, Robin | CCSD

International audience. Background and aims: One-third of hepatocellular carcinomas (HCCs) harbor mutations activating the β-catenin pathway predominantly via mutations in CTNNB1 gene itself. Mouse models of Apc los...

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