Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

Archive ouverte

Marot, Stéphane | Malet, Isabelle | Leducq, Valentin | Zafilaza, Karen | Sterlin, Delphine | Planas, Delphine | Gothland, Adélie | Jary, Aude | Dorgham, Karim | Bruel, Timothée | Burrel, Sonia | Boutolleau, David | Schwartz, Olivier | Gorochov, Guy | Calvez, Vincent | Marcelin, Anne-Geneviève

Edité par CCSD ; Nature Publishing Group -

International audience. There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals are particularly exposed to SARS-CoV-2 infection and at potential risk of reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) and three months (M3) after the onset of symptoms. All the HCW had anti-receptor binding domain (RBD) IgA at D21, decreasing to 38.5% at M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21 and M2 (p = 0.03) and between D21 and M3 (p < 0.0001). Here, we report that SARS-CoV-2 can elicit a NAb response correlated with anti-RBD antibody levels. However, this neutralizing activity declines, and may even be lost, in association with a decrease in systemic IgA antibody levels, from two months after disease onset. This short-lasting humoral protection supports strong recommendations to maintain infection prevention and control measures in HCW, and suggests that periodic boosts of SARS-CoV-2 vaccination may be required.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion