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Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers

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Marot, Stéphane | Malet, Isabelle | Leducq, Valentin | Abdi, Basma | Teyssou, Elisa | Soulie, Cathia | Wirden, Marc | Rodriguez, Christophe | Fourati, Slim | Pawlotsky, Jean-Michel | Boutolleau, David | Burrel, Sonia | Calvez, Vincent | Marcelin, Anne-Geneviève | Jary, Aude

Edité par CCSD ; Oxford University Press (OUP) -

International audience. There are concerns about neutralizing antibodies (NAbs) potency against SARS-CoV-2 variants. Despite decreased NAb titers elicited by BNT162b2-vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCW) had a NAb titer ≥1:10. In contrast, six months after COVID-19 mild-forms, only 9/15 (60%) of HCW displayed detectable NAbs against 501Y.V2 strain.

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