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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

Archive ouverte | Bourdenx, Mathieu | CCSD

International audience. INTRODUCTION:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named L...

Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia

Archive ouverte | Engeln, Michel | CCSD

International audience. BACKGROUND:ΔFosB is a surrogate marker of L-DOPA-induced dyskinesia (LID), the unavoidable disabling consequence of Parkinson's disease L-DOPA long-term treatment. However, the relationship b...

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies

Archive ouverte | Arotcarena, Marie-Laure | CCSD

International audience. The synucleinopathies Parkinson's disease (PD) and Multiple system atrophy (MSA) - characterized by α-synuclein intracytoplasmic inclusions into, respectively, neurons and oligodendrocytes - ...

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