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β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

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Jean-Alphonse, Frédéric | Wehbi, Vanessa | Chen, Jingming | Noda, Masaki | Taboas, Juan | Xiao, Kunhong | Vilardaga, Jean-Pierre

Edité par CCSD ; Nature Publishing Group -

International audience. Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the b2-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein G beta gamma subunits on adenylate cyclase type 2.

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