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MCM9 Is Required for Mammalian DNA Mismatch Repair

Archive ouverte | Traver, Sabine | CCSD

International audience. DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects DNA polymerase errors during replication to maintain genomic integrity. In E. coli, the DNA helicase UvrD is imp...

Identification and Characterisation of Proteins Binding to a G-Quadruplex Origin G-rich Repeated Element in Mammalian Cells

Archive ouverte | Hutchins, James, R A | CCSD

International audience. In metazoan cells, replication of genomic DNA initiates from thousands of discrete chromosomal loci known as origins. Proteins such as the Origin Recognition Complex (ORCs) associate with ori...

Involvement of G-quadruplex regions in mammalian replication origin activity

Archive ouverte | Prorok, Paulina | CCSD

International audience. Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4). Here, we ...

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