Consulter en ligne

Suggestions

Du même auteur

The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination

Archive ouverte | Alvaro-Aranda, Lucia | CCSD

International audience. BRCA2 tumor suppressor protein ensures genome integrity by mediating DNA repair via homologous recombination (HR). This function is executed in part by its canonical DNA binding domain locate...

Replication gap suppression depends on the double-strand DNA binding activity of BRCA2

Archive ouverte | Vugic, Domagoj | CCSD

International audience. Abstract Replication stress (RS) is a major source of genomic instability and is intrinsic to cancer cells. RS is also the consequence of chemotherapeutic drugs for treating cancer. However, ...

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

Archive ouverte | Ehlén, Åsa | CCSD

International audience. The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-like kinase 1 (...

Chargement des enrichissements...