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Cell Biology: Alix ESCRTs Pavarotti During Cell Division

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Addi, Cyril | Echard, Arnaud

Edité par CCSD ; Elsevier -

International audience. Cytokinesis leads to the physical separation of the daughter cells and requires the constriction of ESCRT filaments. How the ESCRT machinery is recruited in non-vertebrate organisms was puzzling, and is now shown to rely on a direct interaction between the ESCRT-associated protein ALIX and the kinesin motor Pavarotti in Drosophila.

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Cytokinesis is the final step that mediates the separation of the two daughter cells after mitosis. It begins with the formation of a cleavage furrow, generated by an actomyosin ring, which leads to the formation of an intercellul...

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