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Deciphering the Glycan Preference of Bacterial Lectins by Glycan Array and Molecular Docking with Validation by Microcalorimetry and Crystallography

Archive ouverte | Topin, Jeremie | CCSD

International audience. Recent advances in glycobiology revealed the essential role of lectins for deciphering the glycocode by specific recognition of carbohydrates. Integrated multiscale approaches are needed for ...

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

Archive ouverte | Wilhelm, Isabel | CCSD

International audience. Bacterial lectins are typically multivalent and bind noncovalently to specific carbohydrates on host tissues to facilitate bacterial adhesion. Here, we analyzed the effects of two fucose-bind...

A Recombinant Fungal Lectin for Labeling Truncated Glycans on Human Cancer Cells

Archive ouverte | Audfray, Aymeric | CCSD

International audience. Cell surface glycoconjugates present alterations of their structures in chronic diseases and distinct oligosaccharide epitopes have been associated with cancer. Among them, truncated glycans ...

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