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Synthesis and anti-Chagas activity profile of a redox-active lead 3benzylmenadione revealed by high-content imaging

Archive ouverte | Trometer, Nathan | CCSD

International audience. Chagas’ disease or American trypanosomiasis is a neglected tropical disease, which is a top priority target of the World Health Organization. The disease, endemic mainly in Latin America, is ...

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones

Archive ouverte | Gendron, Thibault | CCSD

International audience. 2,6-Diaryl-4H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones...

A Platform of Regioselective Methodologies to Access to Polysubstituted 2-Methyl-1,4-Naphthoquinones Derivatives: Scope and Limitations

Archive ouverte | Rodo, Elena Cesar | CCSD

International audience. A platform of synthetic methodologies was established to access a focused library of polysubstituted 3-benzylmenadione derivatives functionalized at the aromatic ring of the naphthoquinone co...

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