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Two cGAS-like receptors induce antiviral immunity in Drosophila

Archive ouverte | Holleufer, Andreas | CCSD

International audience. In mammals, cyclic GMP–AMP (cGAMP) synthase (cGAS) produces the cyclic dinucleotide 2′3′-cGAMP in response to cytosolic DNA and this triggers an antiviral immune response. cGAS belongs to a l...

Investigating the Evolution of Drosophila STING-dependent Antiviral Innate Immunity by Multispecies Comparison of 2′3′-cGAMP Responses

Archive ouverte | Hédelin, Léna | CCSD

International audience. Viruses represent a major threat for all animals, which defend themselves through induction of a large set of virus-stimulated genes that collectively control the infection. In vertebrates, t...

The virus-induced cyclic dinucleotide 2′3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila

Archive ouverte | Cai, Hua | CCSD

International audience. In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the cyclic dinucleotide (CDN) 2030-cGAMP, which triggers STING-dependent immunity. In Drosophila melanogaster,...

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