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Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

Archive ouverte | Manzo, Giorgia | CCSD

International audience. Antimicrobial peptides (AMPs) are a potential source of new molecules to counter the increase in antimicrobial resistant infections but a better understanding of their properties is required ...

A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Archive ouverte | Manzo, Giorgia | CCSD

International audience. Antimicrobial peptides (AMPs) are a potential alternative to classical antibiotics that are yet to achieve a therapeutic breakthrough for treatment of systemic infections. The antibacterial p...

Toward an improved structural model of the frog-skin antimicrobial peptide esculentin-1b(1-18).

Archive ouverte | Manzo, Giorgia | CCSD

International audience. Antimicrobial peptides (AMPs) are found in various classes of organisms as part of the innate immune system. Despite high sequence variability, they share common features such as net positive...

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