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Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus.

Archive ouverte | Monneaux, Fanny | CCSD

We previously demonstrated the importance of the RNP1 motif-bearing region 131-151 of the U1-70K spliceosomal protein in the intramolecular T-B spreading that occurs in MRL/lpr lupus mice. Here, we analyze the involvement of RNP1 ...

Regulatory T cells and systemic lupus erythematosus.

Archive ouverte | Parietti, Véronique | CCSD

Regulatory T cells, especially CD4+CD25+ T cells, "natural killer" T cells and gammadelta T cells, are central in the maintenance of peripheral tolerance and the protection from the development of autoimmune diseases. Numerical or...

Rituximab treatment overcomes reduction of regulatory iNKT cells in patients with rheumatoid arthritis.

Archive ouverte | Parietti, Véronique | CCSD

International audience. Invariant natural killer T (iNKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d molecule. Accumulating evidences showed that iNKT cells are implicated...

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