Afficher la couverture 'Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies. | Tselikas, Lambros' en grand format
/5

0 avis

Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies.

Archive ouverte

Tselikas, Lambros | de Baere, Thierry | Isoardo, Thomas | Susini, Sandrine | Ser-Le Roux, Karine | Polrot, Mélanie | Adam, Julien | Rouanne, Mathieu | Zitvogel, Laurence | Moine, Laurence | Deschamps, Fréderic | Marabelle, Aurélien

Edité par CCSD ; BMJ Publishing Group -

International audience. Intratumorous immunotherapy for cancer is currently thriving. The aim of such local strategy is to improve the therapeutic index of these treatments, for higher on-target/on-tumor activity and less on-target/off-tumor adverse events. Strategies allowing for slow release of anti-CTLA4 in the tumor microenvironment could improve their clinical efficacy.The purpose of the study was to develop a radiopaque delivery platform to improve the targeting and exposure of intratumorous anti-CTLA4 antibodies for cancer immunotherapy.

Suggestions

Du même auteur

BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer

Archive ouverte | Rouanne, Mathieu | CCSD

International audience. Patients with high-risk, nonmuscle-invasive bladder cancer (NMIBC) frequently relapse after standard intravesical bacillus Calmette-Guérin (BCG) therapy and may have a dismal outcome. The mec...

Genomic Instability and Pro-Tumoral Inflammation are associated with Primary Resistance to Anti-PD1 + Anti-Angiogenesis in Malignant Pleural Mesothelioma

Archive ouverte | Danlos, Francois-Xavier | CCSD

International audience. Unlabelled - Cancer immunotherapy combinations have recently been shown to improve the overall survival of advanced mesotheliomas, especially for patients responding to those treatments. We a...

Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers

Archive ouverte | Bredel, Delphine | CCSD

International audience. Background In addition to anti-PD(L)1, anti-CTLA-4 and anti-LAG-3, novel immune checkpoint proteins (ICP)-targeted antibodies have recently failed to demonstrate significant efficacy in clini...

Chargement des enrichissements...