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The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

Archive ouverte | Maurizy, Chloé | CCSD

International audience. The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, i...

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

Archive ouverte | Guo, Yuchen | CCSD

Abstract To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC) we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). Colons of those mice displayed architectural changes in th...

Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer

Archive ouverte | Guo, Yuchen | CCSD

International audience. To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for cyclin A2 in colonic epithelial cells (CECs). Colons of these mice displ...

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