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Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

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Danesin, Cathy | Darche-Gabinaud, Romain | Escalas, Nathalie | Bouguetoch, Vanessa | Cochard, Philippe | Al Oustah, Amir | Ohayon, David | Glise, Bruno | Soula, Cathy

Edité par CCSD -

Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates, a critical regulation level for their role in modulating the activity of signalling molecules. Data presented here define Sulf2a as a novel player in the control of Sonic Hedgehog (Shh)mediated cell type specification during spinal cord development. We show that Sulf2a depletion in

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