Afficher la couverture 'Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome | Chakraborty, Arijita' en grand format
/5

0 avis

Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

Archive ouverte

Chakraborty, Arijita | Jenjaroenpun, Piroon | Li, Jing | El Hilali, Sami | Mcculley, Andrew | Haarer, Brian | Hoffman, Elizabeth | Belak, Aimee | Thorland, Audrey | Hehnly, Heidi | Schildkraut, Carl | Chen, Chun-Long | Kuznetsov, Vladimir A. | Feng, Wenyi

Edité par CCSD ; Elsevier Inc -

International audience. Highlights d Fragile X cells have increased DNA damage with or without DNA replication stress d Break-seq identifies genome-wide DNA double-strand breaks in fragile X cells d Fragile X cells have elevated R-loop formation under DNA replication stress d FMRP, but not a disease-causing FMRP-I304N mutant, reduces R-loop-induced DSBs

Suggestions

Du même auteur

Complementary intestinal mucosa and microbiota responses to caloric restriction

Archive ouverte | Duszka, Kalina | CCSD

International audience. The intestine is key for nutrient absorption and for interactions between the microbiota and its host. Therefore, the intestinal response to caloric restriction (CR) is thought to be more com...

A chromosome-level assembly of the black tiger shrimp ( Penaeus monodon ) genome facilitates the identification of novel growth-associated genes

Archive ouverte | Uengwetwanit, Tanaporn | CCSD

The black tiger shrimp ( Penaeus monodon ) is one of the most prominent farmed crustacean species with an average annual global production of 0.5 million tons in the last decade. To ensure sustainable and profitable production thr...

Chromosome-scale genome assembly and gene annotation of the hydrothermal vent annelid Alvinella pompejana yield insight into animal evolution in extreme environments

Archive ouverte | El Hilali, Sami | CCSD

The types of genomic change needed for environmental adaptation are of great interest. Annelid worms are a large phylum found in a rich diversity of habitats, giving opportunities to explore this issue. We report the chromosome le...

Chargement des enrichissements...