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Tubulin polyglutamylation differentially regulates microtubule-interacting proteins

Archive ouverte | Genova, Mariya | CCSD

International audience. Tubulin posttranslational modifications have been predicted to control cytoskeletal functions by coordinating the molecular inter- actions between microtubules and their associating proteins....

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations

Archive ouverte | Le Dour, Caroline | CCSD

International audience. Mutations in the lamin A/C gene ( LMNA ) cause dilated cardiomyopathy associated with increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates cofilin-1 on thr...

Tubulin glutamylation is key to axon guidance via selective tuning of microtubule-severing enzymes

Archive ouverte | Martin, Daniel Ten | CCSD

International audience. The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-tuned remodelling of this network by selective activation of microtubule-regulating proteins, inclu...

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