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Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

Archive ouverte | Ferren, Marion | CCSD

International audience. Abstract SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also spread to central nerv...

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

Archive ouverte | Mathieu, Cyrille | CCSD

International audience. Measles virus (MeV) infection can cause serious complications in immunocompromised individuals, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacu...

Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

Archive ouverte | Reynard, Olivier | CCSD

Abstract Measles is the most contagious airborne viral infection and the leading cause of child death among vaccine-preventable diseases. We show here that aerosolized lipopeptide fusion inhibitors, derived from heptad-repeat regi...

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