Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

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Mathieu, Cyrille | Bovier, Francesca | Ferren, Marion | Lieberman, Nicole | Predella, Camilla | Lalande, Alexandre | Peddu, Vikas | Lin, Michelle | Addetia, Amin | Patel, Achchhe | Outlaw, Victor | Corneo, Barbara | Dorrello, N. Valerio | Briese, Thomas | Hardie, Diana | Horvat, Branka | Moscona, Anne | Greninger, Alexander | Porotto, Matteo

Edité par CCSD ; American Society for Microbiology -

International audience. Measles virus (MeV) infection can cause serious complications in immunocompromised individuals, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacute sclerosing panencephalitis (SSPE), another severe central nervous system (CNS) complication, develop even in the face of a systemic immune response.

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