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Phosphorylation of Mycobacterial PcaA Inhibits Mycolic Acid Cyclopropanation

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Corrales, Rosa, Milagros | Molle, Virginie | Leiba, Jade | Mourey, Lionel | de Chastellier, Chantal | Kremer, Laurent

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Background: Mycolic acid cyclopropanation plays an important role in mycobacterial virulence but molecular mechanisms controlling cyclopropanation remain unknown. Results: Phosphorylation of the cyclopropane synthase PcaA decreases mycolic acid cyclopropanation and intracellular survival and abrogates the phagosome maturation block (PMB). Conclusion: PMB modulation is dependent on mycobacterial protein phosphorylation. Significance: This study highlights Ser/Thr-dependent phosphorylation of a mycolic acid biosynthetic enzyme in mycobacte-rial virulence.

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