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Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics

Archive ouverte | Molino, Diana | CCSD

International audience. Several human pathologies including neurological, cardiac, infectious , cancerous, and metabolic diseases have been associated with altered mitochondria morphodynamics. Here, we identify a sm...

Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy

Archive ouverte | Pila-Castellanos, Irene | CCSD

International audience. Influenza virus infections are major public health threats due to their high rates of morbidity and mortality. Upon influenza virus entry, host cells experience modifications of endomembranes...

Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery

Archive ouverte | Meyniel-Schicklin, Laurène | CCSD

International audience. We present a drug design strategy based on structural knowledge of protein–protein interfaces selected through virus–host coevolution and translated into highly potential small molecules. Thi...

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