Afficher la couverture 'The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus | Mercier, Romain' en grand format
/5

0 avis

The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus

Archive ouverte

Mercier, Romain | Bautista, Sarah | Delannoy, Maëlle | Gibert, Margaux | Guiseppi, Annick | Herrou, Julien | Mauriello, Emilia | Mignot, Tam

Edité par CCSD ; National Academy of Sciences -

International audience. Type IV pili (Tfp) are highly conserved macromolecular structures that fulfill diverse cellular functions, such as adhesion to host cells, the import of extracellular DNA, kin recognition, and cell motility (twitching). Outstandingly, twitching motility enables a poorly understood process by which highly coordinated groups of hundreds of cells move in cooperative manner, providing a basis for multicellular behaviors, such as biofilm formation. In the social bacteria Myxococcus xanthus, we know that twitching motility is under the dependence of the small GTPase MglA, but the underlying molecular mechanisms remain elusive. Here we show that MglA complexed to GTP recruits a newly characterized Tfp regulator , termed SgmX, to activate Tfp machines at the bacterial cell pole. This mechanism also ensures spatial regulation of Tfp, explaining how MglA switching provokes directional reversals. This discovery paves the way to elucidate how polar Tfp machines are regulated to coordinate multicellular movements, a conserved feature in twitching bacteria. type IV pilus | cell motility | small GTPase | Myxococcus xanthus

Suggestions

Du même auteur

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

Archive ouverte | Guiseppi, Annick | CCSD

International audience. Chemosensory systems are highly organized signaling pathways that allow bacteria to adapt to environmental changes. The Frz chemosensory system from M. xanthus possesses two CheW-like protein...

FrzS acts as a polar beacon to recruit SgmX , a central activator of type IV pili during Myxococcus xanthus motility

Archive ouverte | Bautista, Sarah | CCSD

International audience. In rod-shaped bacteria, type IV pili (Tfp) promote twitching motility by assembling and retracting at the cell pole. In Myxococcus xanthus, a bacterium that moves in highly coordinated cell g...

The differential expression of PilY1 proteins by the HsfBA phosphorelay allows twitching motility in the absence of exopolysaccharides

Archive ouverte | Xue, Shuanghong | CCSD

International audience. Type Four Pili (T4P) are extracellular appendages mediating several bacterial functions such as motility, biofilm formation and infection. The ability to adhere to substrates is essential for...

Chargement des enrichissements...